The foundation:

FACEHBI, a project of Fundació ACE, published by the JPAD


The FACEHBI project has recently been published by the Journal of Prevention of Alzheimer's Disease (JPAD). FACEHBI (ACE Healthy Brain Initiative Foundation) is a study that began in December 2014 and aims to study the subjective memory complaints of 200 people without cognitive impairment, but who notice that they have memory leaks. Over time, it has been proven that acting in the early stages where the person still does not have mild Cognitive Impairment could be key to developing drugs that allow acting later Alzheimer's.

The participants of this study are all over 50 years old and are healthy people who present subjective complaints of memory. However, they should be people who do not present major depression or anxiety, since they are factors that directly interfere in a correct functioning of memory. These people are followed up for two years.

jpad-sideThis study, officially cataloged as a clinical trial, is approved by the Spanish Medicines Agency and the Ethical Committee of the Hospital Clínico de Barcelona.

The study consists of three main phases: when they enter they are given a complete battery of neuropsychological tests, and after one year a follow-up medical visit is made. Finally, when the two years are over, the same battery of tests that he did at the beginning is repeated.

This way is how the study aims to find out if subjective complaints of memory, although they can not be objectified in any error, are a marker of risk and / or make these people more at risk of developing dementia or Alzheimer's. This shall be discovered with patient follow-up for two years, although Fundació ACE does not rule out expanding it any longer in the future.

The other aim of the project is to identify biomarkers (parameters that can be measured, for example in blood or MRI) that can identify the risk of developing dementia or Alzheimer's disease.

This is possible thanks to time tracking by comparing the results of different tests between people who have developed Alzheimer's and those who do not. This study will also allow us to observe the alterations that may manifest in very early stages, when there is still no slight cognitive impairment but subjective complaints of memory.

The publication of FACEHBI in international journals consolidates the value of the study and is a recognition of the advances that will generate initiatives like this.

You might also like

The relationship between retinal thickness and dementia: objective of the latest Fundació ACE study

The prestigious journal Alzheimer's Research & Therapy has published an article by Fundació ACE Research Unit team on the association between the thickness of the retina and the accumulation of the protein β-amyloid in the brain.