The neurology subgroup of the Cohorts for Heart and Aging in Genomic Epidemiology (CHARGE) is a research group working in the replication of studiesof genome-wide associations. The CHARGE consortium formally invited Fundació ACE to join the project neuroCHARGE, that works on phenotypes related to brain pathologies and has already isolated major genes linked to Alzheimer’s disease or cerebrovascular diseases. The CHARD is one of the four consortia forming part of the International Genomics of Alzheimer‘s Project (IGAP).
It is an applied scientific discipline that studies the behavioral expression of brain dysfunction. Itsbased on neuroscience and psychology.
A clinical trial is a research process that, through a controlled scientific method , must be passed by all drugs to test for their efficacy , tolerability and safety before marketing and using the drug in the general population.
Cognitive impairment refers to the decrease in the performance of cognitive functions acquired without affecting the functional capacity for activities of daily life and the previous autonomy of the person. It is a transition stage between normal aging and the appearance of dementia. The research is now studying the percentage and time of conversion of these patients to dementia. The current scientific society assumes cognitive impairment as a previous phase of Alzheimer's disease or other dementias.
Performance of a subject in a cognitive test that is lower than expected for their age and level of schooling. Cognitive test is methodologically measured using scales and cutoffs.