What do we do:
Genomic research

Dr. Agustín Ruiz, Research director

"The main objective of our genomic research group is to understand the causes of Alzheimer's disease and other dementias by integrating genetic, transcriptomic and proteomic data."


The gene bank of Fundació ACE is considered one of the largest in the world in the field of dementia, with more than 20,000 samples stored.

Thanks to the existence of this collection, the genomics laboratory of Fundació ACE presents two lines of research focused on:

1) The search for new genetic targets for the treatment of Alzheimer's disease. GR@ACE project.

We have identified 40 genetic risk factors linked to Alzheimer's. However, these findings are still insufficient to establish the exact mechanism by which this disease is generated.

2) The study of the molecular mechanisms of the APOE gene, the main genetic risk factor for Alzheimer's disease. ADAPTED project.

Apolipoprotein Ԑ4 (APOE) is the main genetic risk factor for Alzheimer's. It is present in 45% of the cases although it is unknown how it intervenes in the development of the pathology. The ADAPTED project, designed and led by our team, uses avant-garde technologies, such as the use of genetically modified stem cells, to discover the mechanism of the APOE gene.