What do we do:
Genomic research

Dr. Agustín Ruiz, Research director

"The main objective of our genomic research group is to understand the causes of Alzheimer's disease and other dementias by integrating genetic, transcriptomic and proteomic data."


The gene bank of Fundació ACE is considered one of the largest in the world in the field of dementia, with more than 20,000 samples stored.

Thanks to the existence of this collection, the genomics laboratory of Fundació ACE presents two lines of research focused on:

1) The search for new genetic targets for the treatment of Alzheimer's disease. GR@ACE project.

We have identified 40 genetic risk factors linked to Alzheimer's. However, these findings are still insufficient to establish the exact mechanism by which this disease is generated.

2) The study of the molecular mechanisms of the APOE gene, the main genetic risk factor for Alzheimer's disease. ADAPTED project.

Apolipoprotein Ԑ4 (APOE) is the main genetic risk factor for Alzheimer's. It is present in 45% of the cases although it is unknown how it intervenes in the development of the pathology. The ADAPTED project, designed and led by our team, uses avant-garde technologies, such as the use of genetically modified stem cells, to discover the mechanism of the APOE gene.

On-going projects


FACEHBI - Fundació ACE Healthy Brain Initiative

FACEHBI (Fundació ACE Healthy Brain Initiative) is a study that began in December 2014. It aims to study the subjective memory complaints of 200 people without cognitive impairment, but who notice a slight memory decline.

PreDADQoL – Ethical and Legal Framework for Predictive Diagnosis of Alzheimer’s Disease: Quality of Life of Individuals at Risk and their Close Others

The PreDADQoL Project wants to elaborate an operative, theoretical and practical framework, that lays the foundations to manage the situations a person will face when he/she is informed he/she will develop Alzheimer's.

MOPEAD - Models Of Patient Engagement for Alzheimer's Disease

The MOPEAD project (of English, Models of Patient Engagement for Alzheimer's Disease) is a European initiative that wants to give the citizen himself an active role in the early detection of the disease.

Clinical utility of 23 loci linked to Alzheimer's disease in subjects at risk of conversion to dementia

The general hypothesis is that the construction of a new genetic predictor, doubling the number of genes relevant to AD, will improve the prediction capabilities of conversion to dementia in MCI subjects suggested in previous studies.