Què fem:
Publicacions científiques

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Sembragiline in Moderate Alzheimer’s Disease: F.I.: 3.92 Results of a Randomized, Double-Blind, Placebo-Controlled Phase II Trial (MAyflOwer RoAD). Nave S, Doody RS, Boada M, Grimmer T, Savola JM, Delmar P, Pauly-Evers M, Nikolcheva T, Czech C, Borroni E, Ricci B, Dukart J, Mannino M, Carey T, Moran E, Gilaberte I, Muelhardt NM, Gerlach I, Santarelli L, Ostrowitzki S, Fontoura P. J Alzheimers Dis. 2017 May 26.. [Epub ahead of print]

Total publicacions.: 19

118,89
Social Representation of Dementia: An Analysis of 5,792 consecutive Cases Evaluated in a Memory Clinic. F.I.: 3.92 Cañabate P, Martínez G, Rosende-Roca M, Moreno M, Preckler S, Valero S, Sotolongo O, Hernández I, Alegret M, Ortega G, Espinosa A, Mauleón A, Vargas L, Rodríguez O, Abdelnour C, Sánchez D, Martín E, Ruiz A, Tárraga L, Boada M. J Alzheimers Dis. 2017 May 17. [Epub ahead of print]

Total publicacions.: 25

127,5

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133.82

Exploring APOE genotype effects on AD risk and beta-amyloid burden in individuals with subjective cognitive decline: the FACEHBI study baseline results.

Alzheimers Dement. 2018 May;14(5):634-643. F. I.: 9.478. doi: 10.1016/j.jalz.2017.10.005. Epub 2017 Nov 20.

Sonia Moreno –Grau, O. Rodríguez-Gomez, A. Sanabria, A. Perez-Cordon, D. Sánchez-Ruiz, C. Abdelnour, S. Valero, I. Hernández, M. Rosende-Roca, A. Mauleón, L. Vargas, A. Lafuente, S. Gil, M. A. Santos-Santos, M. Alegret, A. Espinosa, G. Ortega, M. Guitart, A. Gailhajanet, I. de Rojas, O. Sotolongo-Grau, S. Ruiz, N. Aguilera, J. Papasey, E. Martín, E. Peleja, Alzheimer’s Disease Neuroimaging Initiative*, F. Lomeña, F. Campos, A. Vivas, M.Gomez-Chiari, M.A. Tejero, J. Giménez, M. Serrano-Ríos, A. Orellana, L. Tárraga, A. Ruiz, M.Boada, on behalf of the FACEHBI study group.

Frontotemporal Lobar Degeneration. Review and update for clinical neurologists.

Curr Alzheimer Res. 2018;15(6):511-530. F. I.: 2.952. doi: 10.2174/1567205014666170725130819. Epub 2017 Jul 25.

Hernández I, Fernández MV, Tàrraga L, Boada M, Ruiz A.

Genetic risk for schizophrenia and psychosis in Alzheimer disease.

Mol Psychiatry. 2018 Apr;23(4):963-972. F.I.: 13.204. doi: 10.1038/mp.2017.81. Epub 2017 May 2.

DeMichele-Sweet MAA, Weamer EA, Klei L, Vrana DT, Hollingshead DJ, Seltman HJ, Sims R, Foroud T, Hernandez I, Moreno-Grau S, Tárraga L, Boada M, Ruiz A, Williams J, Mayeux R, Lopez OL, Sibille EL, Kamboh MI, Devlin B, Sweet RA.

A phase III randomized trial of gantenerumab in prodromal Alzheimer's disease.

Alzheimers Res Ther. 2017 Dec 8;9(1):95. F.I.: 6.154. doi: 10.1186/s13195-017-0318-y.

Ostrowitzki S, Lasser RA, Dorflinger E, Scheltens P, Barkhof F, Nikolcheva T, Ashford E, Retout S, Hofmann C, Delmar P, Klein G, Andjelkovic M, Dubois B, Boada M, Blennow K, Santarelli L, Fontoura P; SCarlet RoAD Investigators.

Retinal Microperimetry: A New Tool for Identifying Type 2 Diabetic Patients at Risk of DevelopingAlzheimer´s Disease.

Diabetes. 2017 Dec;66(12):3098-3104. F. I.: 8.684. doi: 10.2337/db17-0382. Epub 2017 Sep 26.

Ciudin A, Simó-Servat O, Hernández C, Arcos G, Diego S, Sanabria Á, Sotolongo Ó, Hernández I, Boada M, Simó R.

18F PET with florbetaben for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI).

Cochrane Database Syst Rev. 2017 Nov 22;11:CD012883. F.I.: 6.12. doi: 10.1002/14651858.CD012883.

Martínez G, Vernooij RW, Fuentes Padilla P, Zamora J, Flicker L, Bonfill Cosp X.

18F PET with flutemetamol for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI).

Cochrane Database Syst Rev. 2017 Nov 22;11:CD012884. F.I.: 6.12. doi: 10.1002/14651858.CD012884.

Martínez G, Vernooij RW, Fuentes Padilla P, Zamora J, Flicker L, Bonfill Cosp X.

18F PET with florbetapir for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI).

Cochrane Database Syst Rev. 2017 Nov 22;11:CD012216. F.I.: 6.12. doi: 10.1002/14651858.CD012216.pub2.

Martínez G, Vernooij RW, Fuentes Padilla P, Zamora J, Bonfill Cosp X, Flicker L.

Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis.

JAMA Neurol. 2017 Oct 1;74(10):1178-1189. F. I.: 10.03. doi: 10.1001/jamaneurol.2017.2188.

Neu SC, Pa J, Kukull W, Beekly D, Kuzma A, Gangadharan P, Wang LS, Romero K, Arneric SP, Redolfi A, Orlandi D, Frisoni GB, Au R, Devine S, Auerbach S, Espinosa A, Boada M, Ruiz A, Johnson SC, Koscik R, Wang JJ, Hsu WC, Chen Y, Toga AW.

Registries and Cohorts to Accelerate Early Phase Alzheimer’s Trials. A Report from the E.U./U.S. Clinical Trials in Alzheimer’s Disease Task Force.

J Prev Alz Dis 2016;3(2):68-74. doi: 10.14283/jpad.2016.97

P. Aisen, J. Touchon, S. Andrieu, M. Boada, R. Doody, R.L. Nosheny, J.B. Langbaum, L. Schneider, S. Hendrix, G. Wilcock, J.L. Molinuevo, C. Ritchie, P.-J. Ousset, J. Cummings, R. Sperling, S.T. DeKosky, S. Lovestone, H. Hampel, R. Petersen, V. Legrand, M. Egan, C. Randolph, S. Salloway, M. Weiner, B. Vellas, and Task Force Members.

A physical model for dementia.

Physica A. 2017 Apr 15;472:86-93. doi:10.1016/j.physa.2016.12.086. Epub 2017 Jan 4.

O. Sotolongo-Costa, L.M. Gaggero-Sager, J.T. Becker, F. Maestuf, O. Sotolongo-Grau, for the Alzheimer’s Disease Neuroimaging Initiative.

The impact of automated hippocampal volumetry on diagnostic confidence in patients with suspected Alzheimer's disease: An EADC study.

Alzheimers Dement. 2017 Sep;13(9):1013-1023. I.F.: 11,619. doi: 10.1016/j.jalz.2017.01.019. Epub 2017

Mar 3 Bosco P, Redolfi A, Bocchetta M, Ferrari C, Mega A, Galluzzi S, Austin M, Chincarini A, Collins DL, Duchesne S, Maréchal B, Roche A, Sensi F, Wolz R, Alegret M, Assal F, Balasa M, Bastin C, Bougea A, Emek-Savaş DD, Engelborghs S, Grimmer T, Grosu G, Kramberger MG, Lawlor B, Mandic Stojmenovic G, Marinescu M, Mecocci P, Molinuevo JL, Morais R, Niemantsverdriet E, Nobili F, Ntovas K, O'Dwyer S, Paraskevas GP, Pelini L, Picco A, Salmon E, Santana I, Sotolongo-Grau O, Spiru L, Stefanova E, Popovic KS, Tsolaki M, Yener GG, Zekry D, Frisoni GB.

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.

Nat Genet. 2017 Sep;49(9):1373-1384. F.I.: 27.959 (2 years). doi: 10.1038/ng.3916. Epub 2017 Jul 17.

Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, Sleegers K, Vronskaya M, Ruiz A, Graham RR, Olaso R, Hoffmann P, Grove ML, Vardarajan BN, Hiltunen M, Nöthen MM, White CC, Hamilton-Nelson KL, Epelbaum J, Maier W, Choi SH, Beecham GW, Dulary C, Herms S, Smith AV, Funk CC, Derbois C, Forstner AJ, Ahmad S, Li H, Bacq D, Harold D, Satizabal CL, Valladares O, Squassina A, Thomas R, Brody JA, Qu L, Sánchez-Juan P, Morgan T, Wolters FJ, Zhao Y, Garcia FS, Denning N, Fornage M, Malamon J, Naranjo MCD, Majounie E, Mosley TH, Dombroski B, Wallon D, Lupton MK, Dupuis J, Whitehead P, Fratiglioni L, Medway C, Jian X, Mukherjee S, Keller L, Brown K, Lin H, Cantwell LB, Panza F, McGuinness B, Moreno-Grau S, Burgess JD, Solfrizzi V, Proitsi P, Adams HH, Allen M, Seripa D, Pastor P, Cupples LA, Price ND, Hannequin D, Frank-García A, Levy D, Chakrabarty P, Caffarra P, Giegling I, Beiser AS, Giedraitis V, Hampel H, Garcia ME, Wang X, Lannfelt L, Mecocci P, Eiriksdottir G, Crane PK, Pasquier F, Boccardi V, Henández I, Barber RC, Scherer M, Tarraga L, Adams PM, Leber M, Chen Y, Albert MS, Riedel-Heller S, Emilsson V, Beekly D, Braae A, Schmidt R, Blacker D, Masullo C, Schmidt H, Doody RS, Spalletta G, Jr WTL, Fairchild TJ, Bossù P, Lopez OL, Frosch MP, Sacchinelli E, Ghetti B, Yang Q, Huebinger RM, Jessen F, Li S, Kamboh MI, Morris J, Sotolongo-Grau O, Katz MJ, Corcoran C, Dunstan M, Braddel A, Thomas C, Meggy A, Marshall R, Gerrish A, Chapman J, Aguilar M, Taylor S, Hill M, Fairén MD, Hodges A, Vellas B, Soininen H, Kloszewska I, Daniilidou M, Uphill J, Patel Y, Hughes JT, Lord J, Turton J, Hartmann AM, Cecchetti R, Fenoglio C, Serpente M, Arcaro M, Caltagirone C, Orfei MD, Ciaramella A, Pichler S, Mayhaus M, Gu W, Lleó A, Fortea J, Blesa R, Barber IS, Brookes K, Cupidi C, Maletta RG, Carrell D, Sorbi S, Moebus S, Urbano M, Pilotto A, Kornhuber J, Bosco P, Todd S, Craig D, Johnston J, Gill M, Lawlor B, Lynch A, Fox NC, Hardy J; ARUK Consortium, Albin RL, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Baldwin CT, Barnes LL, Barral S, Beach TG, Becker JT, Bigio EH, Bird TD, Boeve BF, Bowen JD, Boxer A, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Carroll SL, Diaz CC, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, Dick M, Duara R, Evans DA, Faber KM, Fallon KB, Fardo DW, Farlow MR, Ferris S, Foroud TM, Galasko DR, Gearing M, Geschwind DH, Gilbert JR, Graff-Radford NR, Green RC, Growdon JH, Hamilton RL, Harrell LE, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Abner E, Jin LW, Jun G, Karydas A, Kaye JA, Kim R, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lunetta KL, Lyketsos CG, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Morris JC, Murrell JR, Myers AJ, O'Bryant S, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Perry W, Peskind E, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosen HJ, Rosenberg RN, Sager MA, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Swerdlow RH, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Van Eldik LJ, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Wilhelmsen KC, Williamson J, Wingo TS, Woltjer RL, Wright CB, Yu CE, Yu L, Garzia F, Golamaully F, Septier G, Engelborghs S, Vandenberghe R, De Deyn PP, Fernadez CM, Benito YA, Thonberg H, Forsell C, Lilius L, Kinhult-Stählbom A, Kilander L, Brundin R, Concari L, Helisalmi S, Koivisto AM2, Haapasalo A, Dermecourt V, Fievet N, Hanon O, Dufouil C, Brice A, Ritchie K, Dubois B, Himali JJ, Keene CD, Tschanz J, Fitzpatrick AL, Kukull WA, Norton M, Aspelund T, Larson EB, Munger R, Rotter JI, Lipton RB, Bullido M, Hofman A, Montine TJ, Coto E, Boerwinkle E, Petersen RC, Alvarez V, Rivadeneira F, Reiman EM, Gallo M, O'Donnell C, Reisch JS, Bruni AC, Royall DR, Dichgans M, Sano M, Galimberti D, St George-Hyslop P, Scarpini E, Tsuang DW, Mancuso M, Bonuccelli U, Winslow AR, Daniele A, Wu CK; GERAD/PERADES, CHARGE, ADGC, EADI, Peters O, Nacmias B, Riemenschneider M, Heun R, Brayne C, Rubinsztein DC, Bras J, Guerreiro R, Al-Chalabi A, Shaw CE, Collinge J, Mann D, Tsolaki M, Clarimón J, Sussams R, Lovestone S, O'Donovan MC, Owen MJ, Behrens TW, Mead S, Goate AM, Uitterlinden AG, Holmes C1, Cruchaga C, Ingelsson M, Bennett DA, Powell J, Golde TE, Graff C, De Jager PL, Morgan K, Ertekin-Taner N, Combarros O, Psaty BM, Passmore P, Younkin SG, Berr C, Gudnason V, Rujescu D, Dickson DW, Dartigues JF, DeStefano AL, Ortega-Cubero S, Hakonarson H, Campion D, Boada M, Kauwe JK, Farrer LA, Van Broeckhoven C, Ikram MA, Jones L, Haines JL, Tzourio C, Launer LJ, Escott-Price V, Mayeux R, Deleuze JF, Amin N, Holmans PA, Pericak-Vance MA, Amouyel P, van Duijn CM, Ramirez A, Wang LS, Lambert JC, Seshadri S, Williams J, Schellenberg GD.

Mapping the Health Information Landscape in a Rural, Culturally Diverse Region: Implications for Interventions to Reduce Information Inequality.

J Prim Prev. 2017 Aug;38(4):345-362. I.F.: 1,33. doi: 10.1007/s10935-017-0466-7.

Ramírez AS, Estrada E, Ruiz A.

Type 2 diabetes is an independent risk factor for dementia conversion in patients with mild cognitive impairment.

J Diabetes Complications. 2017 Aug;31(8):1272-1274. F.I.: 2.73. doi: 10.1016/j.jdiacomp.2017.04.018. Epub 2017 Apr 19.

Ciudin A, Espinosa A, Simó-Servat O, Ruiz A, Alegret M, Hernández C, Boada M, Simó R.

Sembragiline in Moderate Alzheimer's Disease: Results of a Randomized, Double-Blind, Placebo-Controlled Phase II Trial (MAyflOwer RoAD).

J Alzheimers Dis. 2017;58(4):1217-1228. F.I.: 3.731. doi: 10.3233/JAD-161309.

Nave S, Doody RS, Boada M, Grimmer T, Savola JM, Delmar P, Pauly-Evers M, Nikolcheva T, Czech C, Borroni E, Ricci B, Dukart J, Mannino M, Carey T, Moran E, Gilaberte I, Muelhardt NM, Gerlach I, Santarelli L, Ostrowitzki S, Fontoura P.

Challenges for Service Robots-Requirements of Elderly Adults with Cognitive Impairments.

Front Neurol. 2017 Jun 1;8:228. F.I.: 6.4. doi: 10.3389/fneur.2017.00228. eCollection 2017.

Korchut A, Szklener S, Abdelnour C, Tantinya N, Hernández-Farigola J, Ribes JC, Skrobas U, Grabowska-Aleksandrowicz K, Szczęśniak-Stańczyk D, Rejdak K.

Social Representation of Dementia: An Analysis of 5,792 Consecutive Cases Evaluated in a Memory Clinic.

J Alzheimers Dis. 2017;58(4):1099-1108. F.I.: 3.731. doi: 10.3233/JAD-161119.

Cañabate P, Martínez G, Rosende-Roca M, Moreno M, Preckler S, Valero S, Sotolongo O, Hernández I, Alegret M, Ortega G, Espinosa A, Mauleón A, Vargas L, Rodríguez O, Abdelnour C, Sánchez D, Martín E, Ruiz A, Tárraga L, Boada M.

Cognitive Composites Domain Scores Related to Neuroimaging Biomarkers within Probable-Amnestic Mild Cognitive Impairment-Storage Subtype.

J Alzheimers Dis. 2017;57(2):447-459. F.I.: 3.731. doi: 10.3233/JAD-161223.

Espinosa A, Alegret M, Pesini P, Valero S, Lafuente A, Buendía M, San José I, Ibarria M, Tejero MA, Giménez J, Ruiz S, Hernández I, Pujadas F, Martínez-Lage P, Munuera J, Arbizu J, Tárraga L, Hendrix SB, Ruiz A, Becker JT, Landau SM, Sotolongo-Grau O, Sarasa M, Boada M.

Impact of Recruitment Methods in Subjective Cognitive Decline.

J Alzheimers Dis. 2017;57(2):625-632. F.I.: 3.731. doi: 10.3233/JAD-160915.

Abdelnour C, Rodríguez-Gómez O, Alegret M, Valero S, Moreno-Grau S, Sanabria Á, Hernández I, Rosende-Roca M, Vargas L, Mauleón A, Sánchez D, Espinosa A, Ortega G, Pérez-Cordón A, Diego S, Gailhajanet A, Guitart M, Sotolongo-Grau Ó, Ruiz A, Tárraga L, Boada M.

Total publicacions.: 34

211,45

Severity dependent distribution of impairments in PSP and CBS: Interactive visualizations.

Parkinsonism and Related Disorders. 2018 Sep 4. pii: S1353-8020(18)30384-5. F.I.: 4.721 doi: 10.1016/j.parkreldis.2018.08.025

Brittain C1, McCarthy A2, Irizarry MC3, McDermott D4, Biglan K3, Höglinger GU5, Lorenzl S6, Del Ser T7, Boxer AL4; AL-108-231 Study Group; PROPSPERA investigators; 4RNTI-1authors; Tau Restoration on PSP (TAUROS) Investigators.



Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease.

Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 2018 Sep 22;10:595-598 doi: 10.1016/j.dadm.2018.08.008.

Peloso GM1, van der Lee SJ2; International Genomics of Alzheimer's Project (IGAP), Destefano AL1,3,4, Seshardi S3,4,5.


Anticancer Agents in Medicine Chemistry.

Anticancer Agents Med Chem. 2018;18(4):591-596. doi: 10.2174/1871520618666180228123406.

Ruiz DS1, Luksch H2, Sifringer M3, Temme A4, Staufner C5, Rzeski W6,7, Marzahn J2, Grabarska A8, Ikonomidou C9, Stepulak A8.



AMPA Receptor Antagonist CFM-2 Decreases Survivin Expression in Cancer Cells.

Anticancer Agents in Medicine Chemistry. 2018;18(4):591-596 F.I.: 2.556 doi: 10.2174/1871520618666180228123406.

Ruiz DS, Luksch H, Sifringer M, Temme A, Staufner C, Rzeski W, Marzahn J, Grabarska A, Ikonomidou C, Stepulak A.

Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia.

Alzheimers Dement. 2018 Dec 13. pii: S1552-5260(18)33563-5. F.I. 12,74 doi: 10.1016/j.jalz.2018.10.003

Slot RER1, Sikkes SAM2, Berkhof J3, Brodaty H4, Buckley R5, Cavedo E6, Dardiotis E7, Guillo-Benarous F8, Hampel H6, Kochan NA9, Lista S6, Luck T10, Maruff P11, Molinuevo JL12, Kornhuber J13, Reisberg B8, Riedel-Heller SG14, Risacher SL15, Roehr S16, Sachdev PS9, Scarmeas N17, Scheltens P1, Shulman MB8, Saykin AJ15, Verfaillie SCJ1, Visser PJ18, Vos SJB19, Wagner M20, Wolfsgruber S20, Jessen F21; Alzheimer's Disease Neuroimaging Initiative, the DESCRIPA working group, the INSIGHT-preAD study group, on behalf of the SCD-I working group, van der Flier WM22.

Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia.

Nat Med. 2018 Dec 3. F.I. 32,62 doi: 10.1038/s41591-018-0223-3

Swarup V1, Hinz FI1, Rexach JE1, Noguchi KI2, Toyoshiba H2, Oda A2, Hirai K2, Sarkar A1, Seyfried NT3,4, Cheng C5, Haggarty SJ5; International Frontotemporal Dementia Genomics Consortium, Grossman M6, Van Deerlin VM7, Trojanowski JQ7, Lah JJ4, Levey AI4, Kondou S2, Geschwind DH8,9,10.

Correlations between plasma and PET beta-amyloid levels in individuals with subjective cognitive decline: the Fundació ACE Healthy Brain Initiative (FACEHBI).

Alzheimers Res Ther. 2018 Nov 29;10(1):119. F.I. 5.015 doi: 10.1186/s13195-018-0444-1

de Rojas I, Romero J, Rodríguez-Gomez O, Pesini P, Sanabria A, Pérez-Cordon A, Abdelnour C, Hernández I, Rosende-Roca M, Mauleón A, Vargas L, Alegret M, Espinosa A, Ortega G, Gil S, Guitart M, Gailhajanet A, Santos-Santos MA, Moreno-Grau S, Sotolongo-Grau O, Ruiz S, Montrreal L, Martín E, Pelejà E, Lomeña F, Campos F, Vivas A, Gómez-Chiari M, Tejero MA, Giménez J, Pérez-Grijalba V, Marquié GM, Monté-Rubio G, Valero S, Orellana A, Tárraga L, Sarasa M, Ruiz A*, Boada M; FACEHBI study. 

Plasma Aβ42/40 Ratio Detects Early Stages of Alzheimer’s Disease and Correlates with CSF and Neuroimaging Biomarkers in the AB255 Study

J Prev Alzheimers Dis. 2019;6(1):34-41. doi: 10.14283/jpad.2018.41.

V. Pérez-Grijalba, J. Romero, P. Pesini, L. Sarasa, I. Monleón, I. San-José, J. Arbizu, P. Martínez-Lage, J. Munuera, A. Ruiz, L. Tárraga, M. Boada, M. Sarasa, on behalf of The AB255 Study Group.

Usefulness of peripapillary nerve fiber layer thickness assessed by optical coherence tomography as a biomarker for Alzheimer's disease.

Nature Scientific Reports. 2018 Nov 5;8(1):16345 F.I.: 4,122 doi:10.1038/s41598-018-34577-3.

Sánchez D1, Castilla-Marti M2,3, Rodríguez-Gómez O4, Valero S4,5, Piferrer A6, Martínez G7,8, Martínez J4, Serra J4, Moreno-Grau S4, Hernández-Olasagarre B4, De Rojas I4, Hernández I4, Abdelnour C4, Rosende-Roca M4, Vargas L4, Mauleón A4, Santos-Santos MA4, Alegret M4, Ortega G4, Espinosa A4, Pérez-Cordón A4, Sanabria Á4, Ciudin A9, Simó R9, Hernández C9, Villaoslada P10, Ruiz A4, Tàrraga L4, Boada M4.

Exploring Genetic Associations of Alzheimer’s Disease Loci With Mild Cognitive Impairment Neurocognitive Endophenotypes.

Frontiers in Aging Neuroscience, 2018 Oct 30;10:340. F.I.: 3.582 doi:10.3389/fnagi.2018.00340. 

Ana Espinosa, Begoña Hernández-Olasagarre1 , Sonia Moreno-Grau1 , Luca Kleineidam2,3,4, Stefanie Heilmann-Heimbach5,6 , Isabel Hernández1 , Steffen Wolfsgruber3,7 , Holger Wagner7 , Maitée Rosende-Roca1 , Ana Mauleón1 , Liliana Vargas1 , Asunción Lafuente1 , Octavio Rodríguez-Gómez1 , Carla Abdelnour1 , Silvia Gil1 , Marta Marquié1 , Miguel A. Santos-Santos1 , Ángela Sanabria1 , Gemma Ortega1 , Gemma Monté-Rubio1 , Alba Pérez1 , Marta Ibarria1 , Susana Ruiz1 , Johannes Kornhuber8 , Oliver Peters9 , Lutz Frölich10, Michael Hüll11 , Jens Wiltfang12 , Tobias Luck13 , Steffi Riedel-Heller14, Laura Montrreal1 , Pilar Cañabate1 , Mariola Moreno1 , Silvia Preckler1 , Nuria Aguilera1 , Itziar de Rojas1 , Adelina Orellana1 , Montserrat Alegret1 , Sergi Valero1 , Markus M. Nöthen5,6, Michael Wagner2,3 , Frank Jessen4,5,7, Lluis Tárraga1 , Mercè Boada1 , Alfredo Ramírez2,4 and Agustín Ruiz1 *.

Pharmacodynamics of atabecestat (JNJ-54861911), an oral BACE1 inhibitor in patients with early Alzheimer's disease: randomized, double-blind, placebo-controlled study.

Alzheimers Res Ther. 2018 Aug 23;10(1):85. F.I. 5.015. doi: 10.1186/s13195-018-0415-6.

Timmers M1,2, Streffer JR3,4,5, Russu A3, Tominaga Y6, Shimizu H6, Shiraishi A6, Tatikola K7, Smekens P3, Börjesson-Hanson A8, Andreasen N9, Matias-Guiu J10, Baquero M11, Boada M12, Tesseur I3, Tritsmans L3, Van Nueten L3, Engelborghs S4,13.

Analysis of shared heritability in common disorders of the brain.

Science. 2018 Jun 22;360(6395). pii: eaap8757 F.I. 41.058. doi: 10.1126/science.aap8757

Brainstorm Consortium, Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, Lee PH, Turley P, Grenier-Boley B, Chouraki V, Kamatani Y, Berr C, Letenneur L, Hannequin D, Amouyel P, Boland A, Deleuze JF, Duron E, Vardarajan BN, Reitz C, Goate AM, Huentelman MJ, Kamboh MI, Larson EB, Rogaeva E, St George-Hyslop P, Hakonarson H, Kukull WA, Farrer LA, Barnes LL, Beach TG, Demirci FY, Head E, Hulette CM, Jicha GA, Kauwe JSK, Kaye JA, Leverenz JB, Levey AI, Lieberman AP, Pankratz VS, Poon WW, Quinn JF, Saykin AJ, Schneider LS, Smith AG, Sonnen JA, Stern RA, Van Deerlin VM, Van Eldik LJ, Harold D, Russo G, Rubinsztein DC, Bayer A, Tsolaki M, Proitsi P, Fox NC, Hampel H, Owen MJ, Mead S, Passmore P, Morgan K, Nöthen MM, Rossor M, Lupton MK, Hoffmann P, Kornhuber J, Lawlor B, McQuillin A, Al-Chalabi A, Bis JC, Ruiz A, Boada M, Seshadri S, Beiser A, Rice K, van der Lee SJ, De Jager PL, Geschwind DH, Riemenschneider M, Riedel-Heller S, Rotter JI, Ransmayr G, Hyman BT, Cruchaga C, Alegret M, Winsvold B, Palta P, Farh KH, Cuenca-Leon E, Furlotte N, Kurth T, Ligthart L, Terwindt GM, Freilinger T, Ran C, Gordon SD, Borck G, Adams HHH, Lehtimäki T, Wedenoja J, Buring JE, Schürks M, Hrafnsdottir M, Hottenga JJ, Penninx B, Artto V, Kaunisto M, Vepsäläinen S, Martin NG, Montgomery GW, Kurki MI, Hämäläinen E, Huang H, Huang J, Sandor C, Webber C, Muller-Myhsok B, Schreiber S, Salomaa V, Loehrer E, Göbel H, Macaya A, Pozo-Rosich P, Hansen T, Werge T, Kaprio J, Metspalu A, Kubisch C, Ferrari MD, Belin AC, van den Maagdenberg AMJM, Zwart JA, Boomsma D, Eriksson N, Olesen J, Chasman DI, Nyholt DR, Avbersek A, Baum L, Berkovic S, Bradfield J, Buono R, Catarino CB, Cossette P, De Jonghe P, Depondt C, Dlugos D, Ferraro TN, French J, Hjalgrim H, Jamnadas-Khoda J, Kälviäinen R, Kunz WS, Lerche H, Leu C, Lindhout D, Lo W, Lowenstein D, McCormack M, Møller RS, Molloy A, Ng PW, Oliver K, Privitera M, Radtke R, Ruppert AK, Sander T, Schachter S, Schankin C, Scheffer I, Schoch S, Sisodiya SM, Smith P, Sperling M, Striano P, Surges R, Thomas GN, Visscher F, Whelan CD, Zara F, Heinzen EL, Marson A, Becker F, Stroink H, Zimprich F, Gasser T, Gibbs R, Heutink P, Martinez M, Morris HR, Sharma M, Ryten M, Mok KY, Pulit S, Bevan S, Holliday E, Attia J, Battey T, Boncoraglio G, Thijs V, Chen WM, Mitchell B, Rothwell P, Sharma P, Sudlow C, Vicente A, Markus H, Kourkoulis C, Pera J, Raffeld M, Silliman S, Boraska Perica V, Thornton LM, Huckins LM, William Rayner N, Lewis CM, Gratacos M, Rybakowski F, Keski-Rahkonen A, Raevuori A, Hudson JI, Reichborn-Kjennerud T, Monteleone P, Karwautz A, Mannik K, Baker JH, O'Toole JK, Trace SE, Davis OSP, Helder SG, Ehrlich S, Herpertz-Dahlmann B, Danner UN, van Elburg AA, Clementi M, Forzan M, Docampo E, Lissowska J, Hauser J, Tortorella A, Maj M, Gonidakis F, Tziouvas K, Papezova H, Yilmaz Z, Wagner G, Cohen-Woods S, Herms S, Julià A, Rabionet R, Dick DM, Ripatti S, Andreassen OA, Espeseth T, Lundervold AJ, Steen VM, Pinto D, Scherer SW, Aschauer H, Schosser A, Alfredsson L, Padyukov L, Halmi KA, Mitchell J, Strober M, Bergen AW, Kaye W, Szatkiewicz JP, Cormand B, Ramos-Quiroga JA, Sánchez-Mora C, Ribasés M, Casas M, Hervas A, Arranz MJ, Haavik J, Zayats T, Johansson S, Williams N, Dempfle A, Rothenberger A, Kuntsi J, Oades RD, Banaschewski T, Franke B, Buitelaar JK, Arias Vasquez A, Doyle AE, Reif A, Lesch KP, Freitag C, Rivero O, Palmason H, Romanos M, Langley K, Rietschel M, Witt SH, Dalsgaard S, Børglum AD, Waldman I, Wilmot B, Molly N, Bau CHD, Crosbie J, Schachar R, Loo SK, McGough JJ, Grevet EH, Medland SE, Robinson E, Weiss LA, Bacchelli E, Bailey A, Bal V, Battaglia A, Betancur C, Bolton P, Cantor R, Celestino-Soper P, Dawson G, De Rubeis S, Duque F, Green A, Klauck SM, Leboyer M, Levitt P, Maestrini E, Mane S, De-Luca DM, Parr J, Regan R, Reichenberg A, Sandin S, Vorstman J, Wassink T, Wijsman E, Cook E, Santangelo S, Delorme R, Rogé B, Magalhaes T, Arking D, Schulze TG, Thompson RC, Strohmaier J, Matthews K, Melle I, Morris D, Blackwood D, McIntosh A, Bergen SE, Schalling M, Jamain S, Maaser A, Fischer SB, Reinbold CS, Fullerton JM, Guzman-Parra J, Mayoral F, Schofield PR, Cichon S, Mühleisen TW, Degenhardt F, Schumacher J, Bauer M, Mitchell PB, Gershon ES, Rice J, Potash JB, Zandi PP, Craddock N, Ferrier IN, Alda M, Rouleau GA, Turecki G, Ophoff R, Pato C, Anjorin A, Stahl E, Leber M, Czerski PM, Cruceanu C, Jones IR, Posthuma D, Andlauer TFM, Forstner AJ, Streit F, Baune BT, Air T, Sinnamon G, Wray NR, MacIntyre DJ, Porteous D, Homuth G, Rivera M, Grove J, Middeldorp CM, Hickie I, Pergadia M, Mehta D, Smit JH, Jansen R, de Geus E, Dunn E, Li QS, Nauck M, Schoevers RA, Beekman AT, Knowles JA, Viktorin A, Arnold P, Barr CL, Bedoya-Berrio G, Bienvenu OJ, Brentani H, Burton C, Camarena B, Cappi C, Cath D, Cavallini M, Cusi D, Darrow S, Denys D, Derks EM, Dietrich A, Fernandez T, Figee M, Freimer N, Gerber G, Grados M, Greenberg E, Hanna GL, Hartmann A, Hirschtritt ME, Hoekstra PJ, Huang A, Huyser C, Illmann C, Jenike M, Kuperman S, Leventhal B, Lochner C, Lyon GJ, Macciardi F, Madruga-Garrido M, Malaty IA, Maras A, McGrath L, Miguel EC, Mir P, Nestadt G, Nicolini H, Okun MS, Pakstis A, Paschou P, Piacentini J, Pittenger C, Plessen K, Ramensky V, Ramos EM, Reus V, Richter MA, Riddle MA, Robertson MM, Roessner V, Rosário M, Samuels JF, Sandor P, Stein DJ, Tsetsos F, Van Nieuwerburgh F, Weatherall S, Wendland JR, Wolanczyk T, Worbe Y, Zai G, Goes FS, McLaughlin N, Nestadt PS, Grabe HJ, Depienne C, Konkashbaev A, Lanzagorta N, Valencia-Duarte A, Bramon E, Buccola N, Cahn W, Cairns M, Chong SA, Cohen D, Crespo-Facorro B, Crowley J, Davidson M, DeLisi L, Dinan T, Donohoe G, Drapeau E, Duan J, Haan L, Hougaard D, Karachanak-Yankova S, Khrunin A, Klovins J, Kučinskas V, Lee Chee Keong J, Limborska S, Loughland C, Lönnqvist J, Maher B, Mattheisen M, McDonald C, Murphy KC, Nenadic I, van Os J, Pantelis C, Pato M, Petryshen T, Quested D, Roussos P, Sanders AR, Schall U, Schwab SG, Sim K, So HC, Stögmann E, Subramaniam M, Toncheva D, Waddington J, Walters J, Weiser M, Cheng W, Cloninger R, Curtis D, Gejman PV, Henskens F, Mattingsdal M, Oh SY, Scott R, Webb B, Breen G, Churchhouse C, Bulik CM, Daly M, Dichgans M, Faraone SV, Guerreiro R, Holmans P, Kendler KS, Koeleman B, Mathews CA, Price A, Scharf J, Sklar P, Williams J, Wood NW, Cotsapas C, Palotie A, Smoller JW, Sullivan P, Rosand J, Corvin A, Neale BM.

Systematic Screening of Ubiquitin/p62 Aggregates in Cerebellar Cortex Expands the Neuropathological Phenotype of the C9orf72 Expansion Mutation.

J Neuropathol Exp Neurol. 2018 Jun 7 F.I.:3.490. doi: 10.1093/jnen/nly047

Ramos-Campoy O1,2, Ávila-Polo R1,3, Grau-Rivera O1,2, Antonell A2, Clarimón J4,5, Rojas-García R6, Charif S1, Santiago-Valera V1, Hernandez I7, Aguilar M8, Almenar C9, Lopez-Villegas D10, Bajo L11, Pastor P8, Van der Zee J12, Lladó A2, Sanchez-Valle R1,2, Gelpi E1,13.

A comparison of various MRI feature types for characterizing whole brain anatomical differences using linear pattern recognition methods.

Neuroimage. 2018 Jun 2. pii: S1053-8119(18)30491-9 F.I.: 5.426. doi: 10.1016/j.neuroimage.2018.05.065.

 Monté-Rubio GC1, Falcón C2, Pomarol-Clotet E3, Ashburner J4.

Genome-wide significant risk factors on chromosome 19 and the APOE locus.

Oncotarget. 2018 May 15;9(37):24590-24600. F.I.: 5.426. doi: 10.18632/oncotarget.25083.

Moreno-Grau S1, Hernández I1, Heilmann-Heimbach S2,3, Ruiz S1, Rosende-Roca M1, Mauleón A1, Vargas L1, Rodríguez-Gómez O1, Alegret M1, Espinosa A1, Ortega G1, Aguilera N1, Abdelnour C1, Neuroimaging Initiative AD1,2,3,4,5,6,7,8,9, Gil S1, Maier W4,5, Sotolongo-Grau O1, Tárraga L1, Ramirez A2,4,6, López-Arrrieta J7, Antúnez C8, Serrano-Ríos M9, Boada M1, Ruiz A1.

Meta-analysis of genetic association with diagnosed Alzheimer's disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing.

BioRxiv. 10.1101/294629 doi10.1101/294629

Brian W. Kunkle, Benjamin Grenier-Boley, Rebecca Sims, Joshua C. Bis, Adam C. Naj, Anne Boland, Maria Vronskaya, Sven J van der Lee, Alex Amlie-Wolf, Celine Bellenguez, Aura Frizatti, Vincent Chouraki, Alzheimer's Disease Genetics Consortium (ADGC), European Alzheimer's Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in Alzheimer's Disease Consortium (GERAD/PERADES), Helena Schmidt, Hakon Hakonarson, Ron Munger, Reinhold Schmidt, Lindsay A. Farrer, Christine Van Broeckhoven, Michael C. O'Donovan, Anita L. Destefano, Lesley Jones, Jonathan L. Haines, Jean-Francois Deleuze, Michael J. Owen, Vilmundur Gudnason, Richard P. Mayeux, Valentina Escott-Price, Bruce M. Psaty, Agustin Ruiz, Alfredo Ramirez, Li-San Wang, Cornelia M. van Duijn, Peter A. Holmans, Sudha Seshadri, Julie Williams, Philippe Amouyel, Gerard D. Schellenberg, Jean-Charles Lambert, Margaret A. Pericak-Vance. BioRxiv.

Common and rare TBK1 variants in early-onset Alzheimer disease in a European cohort.

Neurobiol Aging. 2018 Feb;62:245.e1-245.e7 F.I.: 4.454. doi: 10.1016/j.neurobiolaging.2017.10.012. Epub 2017 Oct 25

Verheijen J1, van der Zee J1, Gijselinck I1, Van den Bossche T2, Dillen L1, Heeman B1, Gómez-Tortosa E3, Lladó A4, Sanchez-Valle R4, Graff C5, Pastor P6, Pastor MA7, Benussi L8, Ghidoni R8, Binetti G9, Clarimon J10, de Mendonça A11, Gelpi E12, Tsolaki M13, Diehl-Schmid J14, Nacmias B15, Almeida MR16, Borroni B17, Matej R18, Ruiz A19, Engelborghs S20, Vandenberghe R21, De Deyn PP20, Cruts M1, Van Broeckhoven C22, Sleegers K23; BELNEU Consortium; EU EOD Consortium.

CXCR4 involvement in neurodegenerative diseases.

Transl Psychiatry. 2018 Apr 11;8(1):73. F.I.: 4.691. doi: 10.1038/s41398-017-0049-7.

Bonham LW1, Karch CM2, Fan CC3, Tan C4, Geier EG1, Wang Y5, Wen N2, Broce IJ4, Li Y4, Barkovich MJ4, Ferrari R6, Hardy J6, Momeni P7, Höglinger G8,9, Müller U10, Hess CP4, Sugrue LP4, Dillon WP4, Schellenberg GD11, Miller BL1, Andreassen OA5, Dale AM3,12, Barkovich AJ4, Yokoyama JS1, Desikan RS13; International FTD-Genomics Consortium (IFGC); International Parkinson’s Disease Genetics Consortium (IPDGC); International Genomics of Alzheimer’s Project (IGAP).

Author Correction: Susceptible genes and disease mechanisms identified in frontotemporal dementia and frontotemporal dementia with Amyotrophic Lateral Sclerosis by DNA-methylation and GWAS.

Sci Rep. 2018 May 14;8(1):7789. F.I.: 4.122. doi: 10.1038/s41598-018-21308-x.

Taskesen E1,2, Mishra A1, van der Sluis S1, Ferrari R3; International FTD-Genomics Consortium, Veldink JH4, van Es MA4, Smit AB5, Posthuma D1,2, Pijnenburg Y6.

Protein network analysis reveals selectively vulnerable regions and biological processes in FTD.

Neurology Genetics. 2018 Oct 1;4(5):e266. doi: 10.1212/NXG.0000000000000266.

Bonham LW1, Steele NZR1, Karch CM1, Manzoni C1, Geier EG1, Wen N1, Ofori-Kuragu A1, Momeni P1, Hardy J1, Miller ZA1, Hess CP1, Lewis P1, Miller BL1, Seeley WW1, Baranzini SE1, Desikan RS1, Ferrari R1, Yokoyama JS1; International FTD-Genomics Consortium (IFGC).



Increased Albumin Oxidation in Cerebrospinal Fluid and Plasma from Alzheimer's Disease Patients.

J Alzheimers Dis. 2018 May 16. F.I.: 3.476. doi: 10.3233/JAD-180243

Costa M1, Horrillo R1, Ortiz AM1, Pérez A1, Mestre A1, Ruiz A2, Boada M2,3, Grancha S1.

Trial of Solanezumab for Mild Dementia Due to Alzheimer's Disease.

N Engl J Med. 2018 Jan 25;378(4):321-330. F.I.: 79.258. doi: 10.1056/NEJMoa1705971.

Honig LS, Vellas B, Woodward M, Boada M, Bullock R, Borrie M, Hager K, Andreasen N, Scarpini E, Liu-Seifert H, Case M, Dean RA, Hake A, Sundell K, Poole Hoffmann V, Carlson C, Khanna R, Mintun M, DeMattos R, Selzler KJ, Siemers E.

Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies.

PLoS Med. 2018 Jan 9;15(1):e1002487. F.I.: 11.675. doi: 10.1371/journal.pmed.1002487. eCollection 2018 Jan.

Broce I, Karch CM, Wen N, Fan CC, Wang Y, Hong Tan C, Kouri N, Ross OA, Höglinger GU, Muller U, Hardy J; International FTD-Genomics Consortium, Momeni P, Hess CP, Dillon WP, Miller ZA, Bonham LW, Rabinovici GD, Rosen HJ, Schellenberg GD, Franke A, Karlsen TH, Veldink JH, Ferrari R, Yokoyama JS, Miller BL, Andreassen OA, Dale AM, Desikan RS, Sugrue LP.

Longitudinal Neuroimaging Analysis in Mild-Moderate Alzheimer's Disease Patients Treated with Plasma Exchange with 5% Human Albumin.

J Alzheimers Dis. 2018;61(1):321-332. F.I.: 3.476. doi: 10.3233/JAD-170693.

Cuberas-Borrós G, Roca I, Boada M, Tárraga L, Hernández I, Buendia M, Rubio L, Torres G, Bittini Á, Guzmán-de-Villoria JA, Pujadas F, Torres M, Núñez L, Castell J, Páez A.

Safety, tolerability and immunogenicity of an active anti-Aβ40 vaccine (ABvac40) in patients with Alzheimer’s disease: a randomised, double-blind, placebo-controlled, phase I trial.

Alzheimers Res Ther. 2018 Jan 29;10(1):12. F.I.: 5.015. doi: 10.1186/s13195-018-0340-8

Ana-María Lacosta, María Pascual-Lucas, Pedro Pesini, Diego Casabona, Virginia Pérez-Grijalba, Iván Marcos-Campos, Leticia Sarasa, Jesus Canudas, Hassnae Badi, Inmaculada Monleón, Itziar San-José, Josep Munuera, Octavio Rodríguez-Gómez, Carla Abdelnour, Asunción Lafuente, Mar Buendía, Mercè Boada, Lluis Tárraga, Agustín Ruiz, Manuel Sarasa.

The Spanish version of Face-Name Associative Memory Exam (S-FNAME) performance is related to amyloid burden in Subjective Cognitive Decline.

Sci Rep. 2018 Feb 28;8(1):3828. F.I.: 4.122. doi: 10.1038/s41598-018-21644-y

Sanabria A, Alegret M, Rodriguez-Gomez O, Valero S, Sotolongo-Grau O, Monté-Rubio G, Abdelnour C, Espinosa A, Ortega G, Perez-Cordon A, Gailhajanet A, Hernandez I, Rosende-Roca M, Vargas L, Mauleon A, Sanchez D, Martin E, Rentz DM, Lomeña F, Ruiz A, Tarraga L, Boada M; FACEHBI study group.

Rare nonsynonymous variants in SORT1 are associated with increased risk for frontotemporaldementia.

Neurobiol Aging. 2018 Jun;66:181.e3-181.e10. F.I.: 4.454. doi:10.1016/j.neurobiolaging.2018.02.011

Philtjens S, Van Mossevelde S, van der Zee J, Wauters E, Dillen L, Vandenbulcke M, Vandenberghe R, Ivanoiu A, Sieben A, Willems C7, Benussi L, Ghidoni R, Binetti G, Borroni B, Padovani A, Pastor P, Diez-Fairen M, Aguilar M, de Mendonça A, Miltenberger-Miltényi G, Hernández I, Boada M, Ruiz A, Nacmias B, Sorbi S, Almeida MR, Santana I, Clarimón J, Lleó A, Frisoni GB, Sanchez-Valle R, Lladó A, Gómez-Tortosa E, Gelpi E, Van den Broeck M, Peeters K, Cras P, De Deyn PP, Engelborghs S, Cruts M, Van Broeckhoven C; BELNEU Consortium; EU EOD Consortium25.

Patient Engagement: The Fundació ACE Framework for Improving Recruitment and Retention in Alzheimer's Disease Research.

J Alzheimers Dis. 2018;62(3):1079-1090. F.I.: 3.476. doi: 10.3233/JAD-170866

Boada M, Santos-Santos MA, Rodríguez-Gómez O, Alegret M, Cañabate P, Lafuente A, Abdelnour C, Buendía M, de Dios MJ, Morera A, Sanabria Á, Campo L, Ruiz A, Tárraga L.

The Role of Verb Fluency in the Detection of Early Cognitive Impairment in Alzheimer's Disease.

J Alzheimers Dis. 2018;62(2):611-619. F.I.:3.476. doi: 10.3233/JAD-170826

Alegret M, Peretó M, Pérez A, Valero S, Espinosa A, Ortega G, Hernández I, Mauleón A, Rosende-Roca M, Vargas L, Rodríguez-Gómez O, Abdelnour C, Berthier ML, Bak TH, Ruíz A, Tárraga L, Boada M.

Los genes de la esquizofrenia que protegen del alzhéimer.

Mente y cerebro, ISSN 1695-0887, Nº. 88, 2018, págs. 32-35

S Moreno, A Ruiz.

Altered topology of the functional speech production network in non-fluent/agrammatic variant of PPA. 

Cortex. 2018 Nov;108:252-264. F.I.: 4.90 doi: 10.1016/j.cortex.2018.08.002

Mandelli ML, Welch AE, Vilaplana E, Watson C, Battistella G, Brown JA, Possin KL, Hubbard HI, Miller ZA, Henry ML, Marx GA, Santos-Santos MA, Bajorek LP, Fortea J, Boxer A, Rabinovici G, Lee S, Deleon J, Rosen HJ, Miller BL, Seeley WW, Gorno-Tempini ML. 



Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia.

Annals of Neurology. 2018 Nov;84(5):729-740. F.I.: 10.24  doi: 10.1002/ana.25333.

Bergeron D, Gorno-Tempini ML, Rabinovici GD, Santos-Santos MA, Seeley W, Miller BL, Pijnenburg Y, Keulen MA, Groot C, van Berckel BNM, van der Flier WM, Scheltens P, Rohrer JD, Warren JD, Schott JM, Fox NC, Sanchez-Valle R, Grau-Rivera O, Gelpi E, Seelaar H, Papma JM, van Swieten JC, Hodges JR, Leyton CE, Piguet O, Rogalski EJ, Mesulam MM, Koric L, Nora K, Pariente J, Dickerson B, Mackenzie IR, Hsiung GR, Belliard S, Irwin DJ, Wolk DA, Grossman M, Jones M, Harris J, Mann D, Snowden JS, Chrem-Mendez P, Calandri IL, Amengual AA, Miguet-Alfonsi C, Magnin E, Magnani G, Santangelo R, Deramecourt V, Pasquier F, Mattsson N, Nilsson C, Hansson O, Keith J, Masellis M, Black SE, Matías-Guiu JA, Cabrera-Martin MN, Paquet C, Dumurgier J, Teichmann M, Sarazin M, Bottlaender M, Dubois B, Rowe CC, Villemagne VL, Vandenberghe R, Granadillo E, Teng E, Mendez M, Meyer PT, Frings L, Lleó A, Blesa R, Fortea J, Seo SW, Diehl-Schmid J, Grimmer T, Frederiksen KS, Sánchez-Juan P, Chételat G, Jansen W, Bouchard RW, Laforce RJ, Visser PJ, Ossenkoppele R.

Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia. 

JAMA Neurology. 2018 Mar 1;75(3):342-352.  F.I.; 11.46   doi: 10.1001/jamaneurol.2017.4309.

Santos-Santos MA, Rabinovici GD, Iaccarino L, Ayakta N, Tammewar G, Lobach I, Henry ML, Hubbard I, Mandelli ML, Spinelli E, Miller ZA, Pressman PS, O'Neil JP, Ghosh P, Lazaris A, Meyer M, Watson C, Yoon SJ, Rosen HJ, Grinberg L, Seeley WW, Miller BL, Jagust WJ, Gorno-Tempini ML. 

Increased Albumin Oxidation in Cerebrospinal Fluid and Plasma from Alzheimer's Disease Patients.

Journal of Alzheimer’s Disease. 2018 May 16.   F.I.: 3.476   doi: 10.3233/JAD-180243.

Costa M, Horrillo R, Ortiz AM, Pérez A, Mestre A, Ruiz A, Boada M, Grancha S. 


Total publicacions.: 4

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Nat Genet. 2019 Mar;51(3):414-430. doi: 10.1038/s41588-019-0358-2. 

Kunkle BW1, Grenier-Boley B2,3,4, Sims R5,6, Bis JC7, Damotte V2,3,4, Naj AC8, Boland A9, Vronskaya M5, van der Lee SJ10, Amlie-Wolf A11, Bellenguez C2,3,4, Frizatti A5, Chouraki V2,3,4,12,13, Martin ER14, Sleegers K15,16, Badarinarayan N5, Jakobsdottir J17, Hamilton-Nelson KL14, Moreno-Grau S18,19, Olaso R9, Raybould R5,6, Chen Y20, Kuzma AB11, Hiltunen M21,22, Morgan T5, Ahmad S10, Vardarajan BN23,24,25, Epelbaum J26, Hoffmann P27,28,29, Boada M18,19, Beecham GW14, Garnier JG9, Harold D30, Fitzpatrick AL31,32, Valladares O11, Moutet ML9, Gerrish A33, Smith AV34,35, Qu L11, Bacq D9, Denning N5,6, Jian X36, Zhao Y11, Del Zompo M37, Fox NC33,38, Choi SH18, Mateo I39, Hughes JT40, Adams HH10, Malamon J11, Sanchez-Garcia F41, Patel Y40, Brody JA7, Dombroski BA11, Naranjo MCD41, Daniilidou M42, Eiriksdottir G17, Mukherjee S43, Wallon D44, Uphill J45, Aspelund T17,46, Cantwell LB11, Garzia F9, Galimberti D47,48, Hofer E49,50, Butkiewicz M51, Fin B9, Scarpini E47,48, Sarnowski C20, Bush WS51, Meslage S9, Kornhuber J52, White CC53, Song Y51, Barber RC54, Engelborghs S55,56, Sordon S57, Voijnovic D10, Adams PM58, Vandenberghe R59, Mayhaus M57, Cupples LA12,20, Albert MS60, De Deyn PP55,56, Gu W57, Himali JJ12,13,20, Beekly D61, Squassina A37, Hartmann AM62, Orellana A18, Blacker D63,64, Rodriguez-Rodriguez E39, Lovestone S65, Garcia ME66, Doody RS67, Munoz-Fernadez C41, Sussams R68, Lin H69, Fairchild TJ70, Benito YA41, Holmes C68, Karamujić-Čomić H10, Frosch MP71, Thonberg H72,73, Maier W74,75, Roschupkin G10, Ghetti B76, Giedraitis V77, Kawalia A78, Li S20, Huebinger RM79, Kilander L77, Moebus S80, Hernández I18,19, Kamboh MI81,82,83, Brundin R77, Turton J84, Yang Q20, Katz MJ85, Concari L86,87, Lord J84, Beiser AS12,13,20, Keene CD88, Helisalmi S21,22, Kloszewska I89, Kukull WA32, Koivisto AM21,22, Lynch A90,91, Tarraga L18,19, Larson EB92, Haapasalo A93, Lawlor B90,91, Mosley TH94, Lipton RB85, Solfrizzi V95, Gill M90,91, Longstreth WT Jr32,96, Montine TJ88, 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Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer disease and three causality networks of AD: the GR@ACE project.

bioRvix. doi:10.1101/528901

Sonia Moreno-Grau, Itziar de Rojas, Isabel Hernandez, Ines Quintela, Laura Montrreal, Montserrat Alegret, Begona Olasagarre, Laura Madrid, Antonio Gonzalez, Olalla Marona, Matiee Rosende-Roca, Ana Mauleon, Liliana Vargas, Asuncion Lafuente, Carla Abdelnour, Octavio Rodriguez-Gonzalez, Silvia Gil, Miguel Angel Santos-Santos, Ana Espinosa, Gemma Ortega, Angela Sanabria, Alba Perez-Cordon, Susana Ruiz, Nuria Aguilera, Juan Antonio Pineda, Juan Macias, Emilio Alarcon-Martin, Oscar Sotolongo-Grau, GR@ACE consortium, DEGESCO consortium, Alzheimer Disease Neuroimaging Initiative, Marta Marquie, Gemma Monte-Rubio, Sergi Valero, Jordi Clarimon, Maria Jesus Bullido, Guillermo Garcia-Ribas, Pau Pastor, Pascual Sanchez-Juan, Victoria Alvarez, Gerard Pinol-Ripoll, Jose Maria Garcia-Alberca, Jose Luis Royo, Emilio Franco, Pablo Mir, Miguel Calero, Miguel Medina, Alberto Rabano, Jesus Avila, Carmen Antunez, Luis Miguel Real, Adelina Orellana, Angel Carracedo, Maria Eugenia Saez, LLuis Tarraga, Merce Boada, Agustin Ruiz.



Plasma exchange for Alzheimer's disease Management by Albumin Replacement (AMBAR) trial: Study design and progress

Alzheimers Dement (N Y). 2019 Feb 26;5:61-69. doi: 10.1016/j.trci.2019.01.001. eCollection 2019.

Boada M, López O, Núñez L, Szczepiorkowski ZM, Torres M, Grifols C, Páez A. 



Plasma Aβ42/40 Ratio Detects Early Stages of Alzheimer's Disease and Correlates with CSF and Neuroimaging Biomarkers in the AB255 Study.

J Prev Alzheimers Dis. 2019;6(1):34-41. doi: 10.14283/jpad.2018.41.

Pérez-Grijalba V1, Romero J, Pesini P, Sarasa L, Monleón I, San-José I, Arbizu J, Martínez-Lage P, Munuera J, Ruiz A, Tárraga L, Boada M, Sarasa M.



Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia.

Nat Med. 2019 Jan;25(1):152-164. doi: 10.1038/s41591-018-0223-3. Epub 2018 Dec 3.

Swarup V, Hinz FI, Rexach JE, Noguchi KI, Toyoshiba H, Oda A, Hirai K, Sarkar A, Seyfried NT, Cheng C, Haggarty SJ; International Frontotemporal Dementia Genomics Consortium, Grossman M, Van Deerlin VM, Trojanowski JQ, Lah JJ, Levey AI, Kondou S, Geschwind DH.